Hacettepe Üniversitesi Eczacılık Fakültesi
Hacettepe Üniversitesi Eczacılık Fakültesi
Farmasötik Kimya Anabilim Dalı Yayınlar
  • Salgin-Goksen U, Telli G, Erikci A, Dedecengiz E, Tel BC, Kaynak FB, Yelekci K, Ucar G, Gokhan-Kelekci N. New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors. J. Med. Chem. 2021; 64(4), 1989-2009.
  • Sari S, Avci A, Koçak E, Kart D, Sabuncuoğlu S, Doğan İS, Özdemir İS, Bozbey İ, Karakurt A, Saraç S, Dalkara S. Antibacterial azole derivatives: Antibacterial activity, cytotoxicity, and in silico mechanistic studies. Drug Dev. Res. 2020;81, 1026–1036.
  • Sari, S., Kart, D., Sabuncuoğlu, S., Doğan, İ.S., Özdemir, Z., Bozbey, İ., Gencel, M., Eşsiz, Ş., Reynisson, J., Karakurt, A., Saraç, S., Dalkara, S., Antifungal screening and in silico mechanistic studies of an in‐house azole library, Chem. Biol. Drug Des. 2019; 94, 1944–1955.
  • Sari, S., Kart, D., Öztürk, N., Kaynak, F.B., Gencel, M., Taşkor, G., Karakurt, A., Saraç, S., Eşsiz, Ş., Dalkara, S., Discovery of new azoles with potent activity against Candida spp. And Candida albicans biofilms through virtual screening, Eur. J. Med. Chem. 2019; 179, 634-648.
  • Acar, M.F., Sari, S., Dalkara, S., Synthesis, in vivo anticonvulsant testing, and molecular modeling studies of new nafimidone derivatives, Drug Dev. Res. 2019; 80 (5), 606-616.
  • Sari, S., Kaynak, F.B., Dalkara, S., Synthesis and anticonvulsant screening of 1,2,4-triazole derivatives, Pharmacol. Rep. 2018; 70 (6), 1116-1123.
  • Doğan, İ.S., Özdemir, Z., Sari, S., Bozbey, İ., Karakurt, A., Saraç S., Synthesis, anticonvulsant activity, and molecular modeling studies of novel 1-phenyl/1-(4-chlorophenyl)-2-(1H-triazol-1-yl)ethanol ester derivatives, Med. Chem. Res. 2018; 27 (9), 2171–2186.
  • Sari, S., Dalkara, S., Kaynak, F.B., Reynisson, J., Saraç, S., Karakurt, A., New Anti‐Seizure (Arylalkyl) azole Derivatives: Synthesis, In Vivo and In Silico Studies, Arch. Pharm. 2017; 350 (6), e1700043.
  • Doğan, İ.S., Saraç, S., Sari, S., Kart, D., Gökhan, S.E., Vural, İ., Dalkara, S., New azole derivatives showing antimicrobial effects and their mechanism of antifungal activity by molecular modeling studies, Eur. J. Med. Chem. 2017; 130, 124–138.
  • Sari, S., Karakurt, A., Uslu, H., Kaynak, F.B., Çalış, Ü., Dalkara, S., New (arylalkyl) azole derivatives showing anticonvulsant effects could have VGSC and/or GABAAR affinity according to molecular modeling studies, Eur. J. Med. Chem. 2016; 124, 407-416.
  • Bargh, Saharnaz ; Silindir-Gunay, M., Ozer, A.Y., Palaska, E., Karaarslan, D., Ide, S., Solpan, D. Physicochemical evaluation of gamma and microwave irradiated dental grafts. Radiat. Phys. Chem. 2020; 170, 108627.
  • Rauf, A., Raza, M., Saleem, M., Erdoğan Orhani İ., Özgen, U., Sezen Karaoğlan, E., Renda, G., Palaska, E.Phytochem. Lett. 2019; 30, 356-361.
  • Renda, G., Özgen, U., Ünal, Z., Sabuncuoğlu, S., Palaska, E., Erdoğan Orhan, İ. Flavonoid Derivatives from the Aerial Parts of Trifolium trichocephalum M. Bieb. and Their Antioxidant and Cytotoxic Activity. Rec. Nat. Prod. 2017;11(5), 479-484.
  • Rauf, A., Raza, M., Saleem, M., Ozgen, U., Karaoglan, E.S., Renda, G., Palaska, E., Orhan, I.E. Carbonic Anhydrase and Urease Inhibitory Potential of Various Plant Phenolics Using in vitro and in silico Methods. Chem. Biodivers. 2017; 14, e1700024.
  • Toz, T., Kiremitçi, A., Çakmak, A.S., Ünsal Tan, O., Palaska, E., Gümüşderelioğlu, M., Özcan, M. A comparative study on monomer elution and cytotoxicity of different adhesive restoration materials. J. Adhes. Sci. Technol. 2017; 31(4), 414-429.
  • Yavuz B, Bozdağ Pehlivan S, Kaffashi A, Çalamak S, Ulubayram K, Palaska E, Çakmak HB, Ünlü N. In vivo tissue distribution and efficacy studies for cyclosporin A loaded nano-decorated subconjunctival implants. Drug Deliv. 2016 Nov;23(9):3279-3284.
  • Yavuz, B., Bozdağ Pehlivan, S., Kaffashi, A., Çalamak, S., Ulubayram, K., Palaska, E., Çakmak, H.B., Ünlü, N. In vivo tissue distribution and efficacy studies for cyclosporin A loaded nano-decorated subconjunctival implants. Drug Deliv. 2016; 23(9), 3279-3284.
  • Unsal-Tan O, Tüylü Küçükkilinç T, Ayazgök B, Balkan A, Ozadali-Sari K. Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer’s disease. MedChemComm. 2019;10(6):1018–26.
  • Özadali Sari, K., Ünsal Tan, O., Sriram, D., Balkan. A. Some new hydrazone derivatives bearing the 1,2,4-triazole moiety as potential antimycobacterial agents. Turkish J Pharm Sci. 2019; 16(4), 432–6.
  • Unsal-Tan, O., Ozadali-Sari, K., Ayazgok, B., Küçükkılınç, T.T., Balkan, A. Novel 2-Arylbenzimidazole derivatives as multi-targeting agents to treat Alzheimer’s disease. Med. Chem. Res. 2017; 26(7), 1506–15.
  • Ozadali-Sari, K., Tüylü Küçükkılınç, T., Ayazgok, B., Balkan, A., Unsal-Tan, O. Novel multi-targeted agents for Alzheimer’s disease: Synthesis, biological evaluation, and molecular modeling of novel 2-[4-(4-substitutedpiperazin-1-yl)phenyl]benzimidazoles. Bioorg. Chem. 2017; 72, 208–14.
  • Ayazgok, B., Kucukkilinc, T.T., Ozadali-Sari, K., Unsal-Tan, O., Balkan, A. Novel benzimidazole derivatives with multi functions on cholinesterase enzymes and neuroprotection. J Neurochem. 2017; 142(S2), 188–225. 
  • Eroglu, B., Ozadali-Sari, K., Unsal-Tan, O., Dharmarajan, S., Yogeeswari, P., Balkan, A. Novel thiazolidinone-azole hybrids: Design, synthesis and antimycobacterial activity studies. Iran. J. Pharm. Res. 2016; 15(4), 783–90.
  • Sirim, M.M., Krishna, V.S., Sriram, D., Unsal Tan, O. Novel benzimidazole-acrylonitrile hybrids and their derivatives: Design, synthesis and antimycobacterial activity.  Eur. J. Med. Chem. 2020; 188, 1120104.
  • Karakaya, G., Ercan A., Oncul S., Aytemir, M.D. Synthesis and Cytotoxic Evaluation of Kojic Acid Derivatives with Inhibitory Activity on Melanogenesis in Human Melanoma Cells. Anticancer Agents Med. Chem. 2018; 18(15), 2137-2148.
  • Karakaya, G., Demirci, A., Ercan A., Oncul S., Aytemir, M.D. Synthesis, Computational Molecular Docking Analysis and Effectiveness on Tyrosinase Inhibition of Kojic Acid Derivatives. Bioorg. Chem. 2019; 88, 102950.
  • Karakaya, G., Ercan A., Oncul S., Aytemir, M.D. Kojic acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation on A375 Human Malignant Melanoma Cells. J. Res. Pharm. 2019; 23(4), 596-607.
  • Oncul, S., Karakaya, G., Aytemir, M.D., Ercan A. A Kojic Acid Derivative Promotes Intrinsic Apoptotic Pathway of Hepatocellular Carcinoma Cells without Incuring Drug Resistance. Chem. Biol. Drug Des. 2019; 94, 2084-2093.
  • Ercan, A., Oncul, S., Karakaya, G., Aytemir, M.D. An Allomaltol Derivative Triggers Distinct Death Pathways in Luminal A and Triple-Negative Breast Cancer Subtypes. Bioorg. Chem. 2020; 105, 1044403.
  • Zengin, M., Unsal-Tan, O., Küçükkılınç, T.T., Ayazgok, B., Balkan, A. Design and Synthesis of 2-Substitutedphenyl Benzo[D]Thiazole Derivatives and Their β-Amyloid Aggregation and Cholinesterase Inhibitory Activities. Pharm. Chem. J. 2019; 53(4), 322-328.
  • Tavakkoli, Z., Goljani, H., Gündüz, M. G., Tahir, M. N., Nematollahi, D. Electrochemical studies of newly synthesized 1,4-dihydropyridine-based hexahydroquinoline derivatives. J. Electrochem. Soc. 2020; 167, 125502.
  • Kale, O.E., Gündüz, M.G., Ogunbiyi, B.T., Ogundare, T.F., Ekor, M., Awodele, O. M. 1,4-Dihydropyridine Derivative and Mixed L-/T-Type Calcium Channel Blocker, Attenuates Isoproterenol-Induced Toxicity in Male Wistar Rats. Cardiovasc. Tox. 2020; 20, 627–640.
  • Knapik-Kowalczuk, J., Gündüz, M. G., Chmiel, K., Jurkiewicz, K, Kurek, M., Tajber, L., Jachowicz, R., Paluch, M. Molecular dynamics, viscoelastic properties and physical stability studies of a new amorphous dihydropyridine derivative with T-type calcium channel blocking activity. Eur. J. Pharm. Sci. 2020; 141, 105083.
  • Aygün Cevher, H., Schaller, D., Gandini, M. A., Kaplan, O., Gambeta, E., Zhang, F. X., Çelebier, M., Tahir, M. N., Zamponi, G. W., Wolber, G., Gündüz, M. G. Discovery of Michael acceptor containing 1,4-dihydropyridines as first covalent inhibitors of L-/T-type calcium channels. Bioor. Chem. 2019; 91, 103187.
  • Gündüz, M.G., Tahir, M.N., Armakovic, S., Özkul Koçak, C., Armakovic, S.J. Design, synthesis and computational analysis of novel acridine-(sulfadiazine/sulfathiazole) hybrids as antibacterial agents. J. Mol. Struct. 2019; 1186, 39-49.
  • Sun, J., Gündüz, M.G., Zhang, J., Yu, J., Guo, X. Direct Enantiomeric Resolution of Seventeen Racemic 1,4-Dihydropyridine-Based Hexahydroquinoline Derivatives by HPLC. Int. J. Mol. Sci. 2019; 20(10), 2513.
  • Ioele, G., Gündüz, M.G., Spatari, C., De Luca, M., Grande, F., Ragno, G. A New Generation of Dihydropyridine Calcium Channel Blockers: Photostabilization of Liquid Formulations Using Nonionic Surfactants. Pharmaceutics. 2019; 11(1), 28.
  • Schaller, D., Gündüz, M.G., Zhang, F.X., Zamponi, G.W., Wolber, G. Binding mechanism investigations guiding the synthesis of novel condensed 1,4-dihydropyridine derivatives with L-/T-type calcium channel blocking activityi. Eur. J. Med. Chem. 2018; 155, 1-12.
  • Yıldırım, S.O., Büyükmumcu, Z., Butcher, R.J., Çetin, G., Şimşek, R. Synthesis and spectroscopic characterization and DFT study of benzyl 4-([1,1’-biphenyl)-4-yl)-2,6,6-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate. J. Mol. Struct. 2020; 1200, 127069
  • Çetin, G., Şimşek, R. Synthesis and biological evaluation of substituted hexahydroquinoline derivatives. Bioorg. Med. Chem. Rep. 2019; 2(1-2), 24-31 
  • Yıldırım, S.O., Büyükmumcu, Z., Butcher, R.J., Çetin, G., Şimşek, R., Şafak, C. Synthesis structural characterization and density functional studies of ethyl 4-(biphenyl-4-yl)-2,6,6-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroqui-noline-3-carboxylate. A non-merohedral twinned structure. J. Mol. Struct. 2018; 1163, 161-166
  • Yıldırım, S.O., Çetin, G., Büyükmumcu, Z., Şimşek, R., Şafak, C., Butcher, R.J., Pakdur, O.S. Experimental and molecular modelling investigation of isopropyl 4-(bphenyl-4-yl)-2,6,6-trimethyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylate. AIP Conf. Proc. 2018; 1935, 040001
  • Özer, E. K., Gündüz, M. G., El-Khouly, A., Sara, Y., Şimşek, R., İskit, A.B., Şafak, C. Synthesis of fused 1,4-dihydropyridines as potential calcium channel blockers. Turk. J. Biochem. 2018; 43(6), 578- 586
  • Baydar, E., Gündüz, M. G., Krishna, V. S., Şimşek, R., Sriram, D., Öztürk Yıldırım, S., Butcher, R. J., Şafak, C. Synthesis, crystal structure and antimycobacterial activities of 4-indolyl-1,4-dihydropyridine derivatives possessing various ester groups. Res. Chem. Intermed. 2017; 43(12), 7471-7489
  • Gündüz, M. G., da Silva, C. B., Zanotto, G. M., Toldo, J. M., Şimşek, R., Şafak, C., Gonçalves, P. F., Rodembusch, F. S. Theoretical and experimental study of the ground and excited states of 1,4-dihydropyridine based hexahydroquinoline derivatives achieved by microwave irradiation. New J. Chem. 2017; 41, 11686-11694
  • Gündüz, M. G., Ragno, G., Şimşek, R., De Luca, M., Safak, C., Grande, F., El-Khouly, A., İşli, F., Yıldırım, Ş., Öztürk Fincan, G. S., Ioele, G. Synthesis and photodegradation studies of analogues of muscle relaxant 1,4-dihydropyridine compounds. Acta Pharm. 2017; 67(3), 341-355, 2017.
  • Şimşek, R., Gündüz, M. G., Şafak, C., Kökpınar, Ö., Aydın, M. Free radicals properties of some gamma-irradiated organic compounds. Bulg. Chem. Commun. 2017; 49(1), 82-86
  • Gündüz, M.G., Kaya, Y., Şimşek, R., Sahin-Erdemli, I., Şafak, C. Synthesis and Biological Evaluation of New Tricyclic Dihydropyridine Based Derivatives on Potassium Channels. Iran. J. Pharm. Sci. 2016; 15(4), 763-775.
  • Ioele, G., Gündüz, M. G.,  De Luca, M., Şimşek, R., Şafak, C., Muzzalupo, R., Ragno, G. Photodegradation studies of 1,4-dihydropyridine compounds by MCR analysis on UV spectral data. Future Med. Chem. 2016, 8(2), 107-115.
  • Gündüz, M. G., Albayrak, E., İşli, F., Öztürk Fincan, G. S., Yıldırım, Ş., Şimşek, R., Şafak, C., Sarıoğlu, Y., Öztürk Yıldırım, S., Butcher, R. J. Synthesis, structural characterization and myorelaxant activity of 4-naphthyl-hexahydroquinoline derivatives containing different ester groups. J. Serb. Chem. Soc. 2016; 81(7), 729-738
  • Avci, A., Taşci, H., Kandemir, Ü., Can, Ö.D., Gökhan-Kelekçi, N., Tozkoparan, B. Synthesis, characterization, and in vivo pharmacological evaluation of novel mannich bases derived from 1,2,4-triazole containing a naproxen moiety. Bioorg. Chem. 2020; 100, 103892.
  • Teke-Tunçel, Ş., Günal, E., Ekizoğlu, M., Uçar, G., Gökhan-Kelekçi, N., Sağ-Erdem, S., Bulak, E., Frey, W., Doğan İ. Thioureas and their cyclized derivatives: Synthesis, conformational analysis and antimicrobial evaluation. J. Mol. Struct. 2019; 1179, 40-56.
  • Salgın-Gökşen, U., Sarıgül, S., Bultinck, P., Herrebout, W., Doğan, İ., Yelekçi, K., Uçar, G., Gökhan-Kelekçi, N. Absolute configuration and biological profile of pyrazoline enantiomers as MAO inhibitory activity. Chirality. 2019; 31(1), 21-33.
  • Günal, E., Teke-Tunçel, Ş., Gökhan-Kelekçi, N., Uçar, G., Yüce, B.D., Sağ-Erdem, S., Doğan, İ. Asymmetric synthesis, molecular modeling and biological evaluation of 5-methyl-3-aryloxazolidine-2,4-dione enantiomers as monoamine oxidase (MAO) inhibitors. Bioorg. Chem. 2018; 17, 608-618
  • Tasci, H., Gökhan Kelekçi, N. MAO-B Inhibitörleri: Yapı-aktivite Çalışmaları ve Nörolojik Bozuklukların Tedavisindeki Rolü. FABAD J. Pharm. Sci. 2017; 42(3), 249-287.
  • Gundogdu, G., Karayel, A., Aytac, SP., Tozkoparan, B., Kaynak, FB. Synthesis and structural characterization of 3-[1-[4-(2-methylpropyl)phenyl] ethyl]-6-(4-fluorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole. Powder Diffr. 2019; 34(4), 325-330
  • Kahraman, D. C., Guven, E. B., Aytac, P., Tozkoparan, B., Atalay, R. C. A New Thiadiazine Derivative Induces Oxidative Stress Dependent Cell Death In Hepatocellular Carcinoma Stem Cells, Hepatology. 2019; 70, 1108A
  • Kahraman, D. C., Guven, E. B., Tozkoparan, B., Atalay, R. C. A new thiadiazine derivative induces oxidative stress dependent JNK pathway activation and cell death in hepatocellular carcinoma, Cancer Res. 2019; 79, 13.
  • Gundogdu, G., Aytac, S. P., Muller, M., Tozkoparan, B., Kaynak, F. B. Structure elucidation of 3-[1-(6-methoxy-2-naphtyl)ethyl]-6-(2,4-dichlorophenyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine, C23H18Cl2N4OS from synchrotron X-ray powder diffraction. Powder Diffr. 2017; 32, 4, 271-278
  • Sert-Ozgur, S., Tel, B. C., Somuncuoglu, E. I., Kazkayas, I., Ertan, M., Tozkoparan, B. Design And Synthesis Of 1,2,4-Triazolo[3,2-B]-1,3,5-Thiadiazine Derivatives As A Novel Template For Analgesic/Anti-Inflammatory Activity. Archiv Der Pharmazie, 2017; 350, 7, 0365-6233
  • Gundogdu, G., Aytac, S. P., Mueller, M., Tozkoparan, B. Kaynak, F. B. Structure determination of two structural analogs, named 3-[1-(2-fluoro-4- biphenyl)ethyl]-6-(4-fluorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (C23H16F2N4S) and 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-chlorophenyl)-1,2,4- triazolo[3,4-b]-1,3,4-thiadiazole (C23H16ClFN4S) by synchrotron X-ray powder diffraction. Powder Diffr. 2017; 32, 4, 279-289
  • Gundogdu, G., Aytac, S. P., Mueller, M., Tozkoparan, B. Kaynak, F. B. Structure Elucidation Of 3-[1-(6-Methoxy-2-Naphtyl)Ethyl]-6-(2,4- Dichlorophenyl)-7h-1,2,4-Triazolo[3,4-B]-1,3,4-Thiadiazine,  C23h18cl2n4os From Synchrotron X-Ray Powder Diffraction, Powder Diffr. 2017; 32, 4, 271-278.
  • Aytac, P. S., Durmaz, I., Houston, D. R., Cet N-Atalay, R. Tozkoparan, B. Novel Triazolothiadiazines Act As Potent Anticancer Agents İn Liver Cancer Cells Through Akt And ASK-1 Proteins, Bioorg. Med. Chem. 2016; 24, 4, 858-872.
  • Sarigol, D., Uzgoren-Baran, A., Tel, B. C., Somuncuoglu, E. I., Kazkayas, I., Ozadali -Sari, K., Unsal-Tan, O., Okay, G., Ertan, M., Tozkoparan, B. Novel Thiazolo[3,2-B]-1,2,4-Triazoles Derived From Naproxen With Analgesic/Anti- İnflammatory Properties: Synthesis, Biological Evaluation And Molecular Modeling Studies, Bioorg. Med. Chem. 2015; 23, 10, 2518-2528.